miR-21 coordinates tumor growth and modulates KRIT1 levels

miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 sil...

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Detalles Bibliográficos
Autores principales: Orso, Francesca, Balzac, Fiorella, Marino, Marco, Lembo, Antonio, Retta, Saverio Francesco, Taverna, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750217/
https://www.ncbi.nlm.nih.gov/pubmed/23872064
http://dx.doi.org/10.1016/j.bbrc.2013.07.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750217/
https://www.ncbi.nlm.nih.gov/pubmed/23872064
http://dx.doi.org/10.1016/j.bbrc.2013.07.031

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