Cargando…
Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence
BACKGROUND: Subterranean blind mole rats (Spalax) are hypoxia tolerant (down to 3% O(2)), long lived (>20 years) rodents showing no clear signs of aging or aging related disorders. In 50 years of Spalax research, spontaneous tumors have never been recorded among thousands of individuals. Here we...
Autores principales: | Manov, Irena, Hirsh, Mark, Iancu, Theodore C, Malik, Assaf, Sotnichenko, Nick, Band, Mark, Avivi, Aaron, Shams, Imad |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750378/ https://www.ncbi.nlm.nih.gov/pubmed/23937926 http://dx.doi.org/10.1186/1741-7007-11-91 |
Ejemplares similares
-
Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax
por: Domankevich, Vered, et al.
Publicado: (2016) -
Transcriptome Sequencing of the Blind Subterranean Mole Rat, Spalax galili: Utility and Potential for the Discovery of Novel Evolutionary Patterns
por: Malik, Assaf, et al.
Publicado: (2011) -
Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax
por: Odeh, Amani, et al.
Publicado: (2019) -
Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response
por: Odeh, Amani, et al.
Publicado: (2023) -
Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach
por: Schmidt, Hanno, et al.
Publicado: (2017)