MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells

BACKGROUND: Thymidylate synthase (TYMS) is an important folate-dependent enzyme in DNA synthesis and an important target for cancer chemotherapy. High TYMS expression levels in tumors are generally associated with resistance to 5-fluorouracil (5-FU). The cause of the variability in TYMS expression i...

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Detalles Bibliográficos
Autores principales: Gotanda, Keisuke, Hirota, Takeshi, Matsumoto, Nozomi, Ieiri, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750578/
https://www.ncbi.nlm.nih.gov/pubmed/23915286
http://dx.doi.org/10.1186/1471-2407-13-369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750578/
https://www.ncbi.nlm.nih.gov/pubmed/23915286
http://dx.doi.org/10.1186/1471-2407-13-369

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