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MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells

BACKGROUND: Thymidylate synthase (TYMS) is an important folate-dependent enzyme in DNA synthesis and an important target for cancer chemotherapy. High TYMS expression levels in tumors are generally associated with resistance to 5-fluorouracil (5-FU). The cause of the variability in TYMS expression i...

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Detalles Bibliográficos
Autores principales:	Gotanda, Keisuke, Hirota, Takeshi, Matsumoto, Nozomi, Ieiri, Ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750578/ https://www.ncbi.nlm.nih.gov/pubmed/23915286 http://dx.doi.org/10.1186/1471-2407-13-369

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