Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension

BACKGROUND: Lack of power and reproducibility are caveats of genetic association studies of common complex diseases. Indeed, the heterogeneity of disease etiology demands that causal models consider the simultaneous involvement of multiple genes. Rothman’s sufficient-cause model, which is well known...

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Detalles Bibliográficos
Autores principales: Lynn, Ke-Shiuan, Lu, Chen-Hua, Yang, Han-Ying, Hsu, Wen-Lian, Pan, Wen-Harn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751083/
https://www.ncbi.nlm.nih.gov/pubmed/23879630
http://dx.doi.org/10.1186/1471-2164-14-497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751083/
https://www.ncbi.nlm.nih.gov/pubmed/23879630
http://dx.doi.org/10.1186/1471-2164-14-497

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