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Construction of gene clusters resembling genetic causal mechanisms for common complex disease with an application to young-onset hypertension
BACKGROUND: Lack of power and reproducibility are caveats of genetic association studies of common complex diseases. Indeed, the heterogeneity of disease etiology demands that causal models consider the simultaneous involvement of multiple genes. Rothman’s sufficient-cause model, which is well known...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751083/ https://www.ncbi.nlm.nih.gov/pubmed/23879630 http://dx.doi.org/10.1186/1471-2164-14-497 |