A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

BACKGROUND: Tetherin (or BST-2) is an antiviral host restriction factor that suppresses the release of HIV-1 and other enveloped viruses by tethering them to the cell surface. Recently, it has been demonstrated that tetherin also acts as an innate sensor of HIV-1 assembly that induces NF-κB-dependen...

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Detalles Bibliográficos
Autores principales: Sauter, Daniel, Hotter, Dominik, Engelhart, Susanne, Giehler, Fabian, Kieser, Arnd, Kubisch, Christian, Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751106/
https://www.ncbi.nlm.nih.gov/pubmed/23937976
http://dx.doi.org/10.1186/1742-4690-10-85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751106/
https://www.ncbi.nlm.nih.gov/pubmed/23937976
http://dx.doi.org/10.1186/1742-4690-10-85

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