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A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release
BACKGROUND: Tetherin (or BST-2) is an antiviral host restriction factor that suppresses the release of HIV-1 and other enveloped viruses by tethering them to the cell surface. Recently, it has been demonstrated that tetherin also acts as an innate sensor of HIV-1 assembly that induces NF-κB-dependen...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751106/ https://www.ncbi.nlm.nih.gov/pubmed/23937976 http://dx.doi.org/10.1186/1742-4690-10-85 |