Sources of bias in measures of allele-specific expression derived from RNA-seq data aligned to a single reference genome

BACKGROUND: RNA-seq can be used to measure allele-specific expression (ASE) by assigning sequence reads to individual alleles; however, relative ASE is systematically biased when sequence reads are aligned to a single reference genome. Aligning sequence reads to both parental genomes can eliminate t...

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Detalles Bibliográficos
Autores principales: Stevenson, Kraig R, Coolon, Joseph D, Wittkopp, Patricia J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751238/
https://www.ncbi.nlm.nih.gov/pubmed/23919664
http://dx.doi.org/10.1186/1471-2164-14-536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751238/
https://www.ncbi.nlm.nih.gov/pubmed/23919664
http://dx.doi.org/10.1186/1471-2164-14-536

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