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Sources of bias in measures of allele-specific expression derived from RNA-seq data aligned to a single reference genome
BACKGROUND: RNA-seq can be used to measure allele-specific expression (ASE) by assigning sequence reads to individual alleles; however, relative ASE is systematically biased when sequence reads are aligned to a single reference genome. Aligning sequence reads to both parental genomes can eliminate t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751238/ https://www.ncbi.nlm.nih.gov/pubmed/23919664 http://dx.doi.org/10.1186/1471-2164-14-536 |