Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain

BACKGROUND: Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial respiratory chain (MRC). The mechanisms of the latter effects are unclear. The aim of this study was to determine...

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Detalles Bibliográficos
Autores principales: García-Ruiz, Inmaculada, Solís-Muñoz, Pablo, Fernández-Moreira, Daniel, Muñoz-Yagüe, Teresa, Solís-Herruzo, José A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751493/
https://www.ncbi.nlm.nih.gov/pubmed/23915000
http://dx.doi.org/10.1186/1741-7007-11-88

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751493/
https://www.ncbi.nlm.nih.gov/pubmed/23915000
http://dx.doi.org/10.1186/1741-7007-11-88

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