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Synthesis and evaluation of [(11)C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain
BACKGROUND: Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [(11)C]MMPIP, a putative radioligand for mGlu7 (binding constant K(B) = 30 nM), and evaluated its po...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751550/ https://www.ncbi.nlm.nih.gov/pubmed/23870677 http://dx.doi.org/10.1186/2191-219X-3-54 |