The Role of Phospholipase D in Modulating the MTOR Signaling Pathway in Polycystic Kidney Disease

The mammalian target of rapamycin (mTOR) signaling pathway is aberrantly activated in polycystic kidney disease (PKD). Emerging evidence suggests that phospholipase D (PLD) and its product phosphatidic acid (PA) regulate mTOR activity. In this study, we assessed in vitro the regulatory function of P...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Käch, Andres, Ziegler, Urs, Ong, Albert C. M., Wallace, Darren P., Arcaro, Alexandre, Serra, Andreas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751888/
https://www.ncbi.nlm.nih.gov/pubmed/24009738
http://dx.doi.org/10.1371/journal.pone.0073173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751888/
https://www.ncbi.nlm.nih.gov/pubmed/24009738
http://dx.doi.org/10.1371/journal.pone.0073173

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