Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli

OBJECTIVE: Overexpression of the sonic hedgehog (SHH) signaling pathway is an essential characteristic of pancreatic cancer stem cells (PCSCs) and arsenic trioxide (ATO) is described as a SHH inhibitor. This study evaluates whether ATO has the potential to inhibit viability of PCSCs via binding to S...

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Detalles Bibliográficos
Autores principales: Han, Jin-bin, Sang, Feng, Chang, Jin-jia, Hua, Yong-qiang, Shi, Wei-dong, Tang, Li-hua, Liu, Lu-ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753152/
https://www.ncbi.nlm.nih.gov/pubmed/23990729
http://dx.doi.org/10.2147/OTT.S49148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753152/
https://www.ncbi.nlm.nih.gov/pubmed/23990729
http://dx.doi.org/10.2147/OTT.S49148

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