Cargando…

Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli

OBJECTIVE: Overexpression of the sonic hedgehog (SHH) signaling pathway is an essential characteristic of pancreatic cancer stem cells (PCSCs) and arsenic trioxide (ATO) is described as a SHH inhibitor. This study evaluates whether ATO has the potential to inhibit viability of PCSCs via binding to S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Jin-bin, Sang, Feng, Chang, Jin-jia, Hua, Yong-qiang, Shi, Wei-dong, Tang, Li-hua, Liu, Lu-ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753152/ https://www.ncbi.nlm.nih.gov/pubmed/23990729 http://dx.doi.org/10.2147/OTT.S49148

Ejemplares similares

Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts
por: Tang, Renyan, et al.
Publicado: (2021)

Immunosuppressive effect of arsenic trioxide on islet xenotransplantation prolongs xenograft survival in mice
por: Zhao, Bin, et al.
Publicado: (2018)

Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup
por: dos Santos Klinger, Paulo Henrique, et al.
Publicado: (2020)

Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation
por: Nakamura, Shunsuke, et al.
Publicado: (2013)

Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling
por: Nogueira, Raphael Luís Rocha, et al.
Publicado: (2022)

Evaluation of the target genes of arsenic trioxide in pancreatic cancer by bioinformatics analysis
por: Zhou, Cong-Ya, et al.
Publicado: (2019)

Spatiotemporal Expression of SHH/GLI Signaling in Human Fetal Bladder Development
por: Zhang, Haibao, et al.
Publicado: (2021)

Gli2-Mediated Shh Signaling Is Required for Thalamocortical Projection Guidance
por: Callejas-Marin, Antuca, et al.
Publicado: (2022)

Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002
por: Cai, Xinyi, et al.
Publicado: (2015)

Co-treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of nasopharyngeal carcinoma
por: Sides, Mark D, et al.
Publicado: (2013)

hsa-miR-203 enhances the sensitivity of leukemia cells to arsenic trioxide
por: HE, JIN-HUA, et al.
Publicado: (2013)

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Arsenic trioxide alters the differentiation of mouse embryonic stem cell into cardiomyocytes
por: Rebuzzini, Paola, et al.
Publicado: (2015)

Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
por: Cohen, Michael, et al.
Publicado: (2015)

Immunohistochemical analysis of SHH, SMO and GLI-1 proteins in epithelial odontogenic lesions
por: Rodrigues, Katianne Soares, et al.
Publicado: (2022)

Arsenic speciation in saliva of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment
por: Chen, Baowei, et al.
Publicado: (2013)

Protective effects of oxymatrine against arsenic trioxide-induced liver injury
por: Li, Li, et al.
Publicado: (2016)

CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma
por: Zhao, Jungang, et al.
Publicado: (2022)

Evidences of Protective Potentials of Microdoses of Ultra-High Diluted Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic Trioxide
por: Banerjee, Pathikrit, et al.
Publicado: (2011)

Establishment and characterization of arsenic trioxide resistant KB/ATO cells
por: Zhang, Yun-Kai, et al.
Publicado: (2017)

Arsenic trioxide induces differentiation of CD133(+) hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model
por: Zhang, Ke-Zhi, et al.
Publicado: (2014)

Arsenic trioxide and triptolide synergistically induce apoptosis in the SKM-1 human myelodysplastic syndrome cell line
por: Hua, Hai-Ying, et al.
Publicado: (2016)

Combined application of arsenic trioxide and lithium chloride augments viability reduction and apoptosis induction in human rhabdomyosarcoma cell lines
por: Schleicher, Sabine B., et al.
Publicado: (2017)

Acute toxicity of intratracheal arsenic trioxide instillation in rat lungs
por: Mingxing, Su, et al.
Publicado: (2019)

In silico mechanisms of arsenic trioxide-induced cardiotoxicity
por: Li, Yacong, et al.
Publicado: (2022)

Arsenic trioxide as an inducer of immunogenic cell death
por: Kepp, Oliver, et al.
Publicado: (2023)

Immunological consequences of arsenic trioxide-induced necrosis
por: Gavali, Shubhangi, et al.
Publicado: (2023)

Yeast-based assay identifies novel Shh/Gli target genes in vertebrate development
por: Milla, Luis A, et al.
Publicado: (2012)

MBRS-06. Gli3 INDUCES NEURONAL DIFFERENTIATION IN WNT- AND SHH- ACTIVATED MEDULLOBLASTOMA
por: Natsumeda, Manabu, et al.
Publicado: (2020)

Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres
por: Ding, Dacheng, et al.
Publicado: (2014)

A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells
por: Dias, José M., et al.
Publicado: (2020)

Retracted: Evidences of Protective Potentials of Microdoses of Ultra-High Diluted Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic Trioxide
por: Medicine, Evidence-Based Complementary and Alternative
Publicado: (2021)

Arsenic trioxide rewires mantle cell lymphoma response to bortezomib
por: Zhao, Ling-Ling, et al.
Publicado: (2015)

Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells
por: Riaz, Syeda Kiran, et al.
Publicado: (2019)

Inhibitory Effects of Rhein on Renal Interstitial Fibrosis via the SHH-Gli1 Signal Pathway
por: Luo, Yan, et al.
Publicado: (2022)

Enhancement of Arsenic Trioxide-Mediated Changes in Human Induced Pluripotent Stem Cells (IPS)
por: Graham, Barbara, et al.
Publicado: (2014)

Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide
por: Zheng, Yu, et al.
Publicado: (2021)

Oxidative stress induced by the chemotherapeutic agent arsenic trioxide
por: Varghese, Mathews V., et al.
Publicado: (2013)

Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor
por: Yoshimura, Yayoi, et al.
Publicado: (2015)

A Review of Arsenic Trioxide and Acute Promyelocytic Leukemia
por: Alimoghaddam, Kamran
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_lufvu7r986qevmf5esm5or9ft8