Enhancing Production and Cytotoxic Activity of Polymeric Soluble FasL-Based Chimeric Proteins by Concomitant Expression of Soluble FasL

Membrane FasL is the natural trigger of Fas-mediated apoptosis. A soluble homotrimeric counterpart (sFasL) also exists which is very weakly active, and needs oligomerization beyond its trimeric state to induce apoptosis. We recently generated a soluble FasL chimera by fusing the immunoglobulin-like...

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Detalles Bibliográficos
Autores principales: Morello, Aurore, Daburon, Sophie, Castroviejo, Michel, Moreau, Jean-François, Dechanet-Merville, Julie, Taupin, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753252/
https://www.ncbi.nlm.nih.gov/pubmed/23991192
http://dx.doi.org/10.1371/journal.pone.0073375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753252/
https://www.ncbi.nlm.nih.gov/pubmed/23991192
http://dx.doi.org/10.1371/journal.pone.0073375

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