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High Yield Production of a Soluble Human Interleukin-3 Variant from E. coli with Wild-Type Bioactivity and Improved Radiolabeling Properties

Human interleukin-3 (hIL-3) is a polypeptide growth factor that regulates the proliferation, differentiation, survival and function of hematopoietic progenitors and many mature blood cell lineages. Although recombinant hIL-3 is a widely used laboratory reagent in hematology, standard methods for its...

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Detalles Bibliográficos
Autores principales: Hercus, Timothy R., Barry, Emma F., Dottore, Mara, McClure, Barbara J., Webb, Andrew I., Lopez, Angel F., Young, Ian G., Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753260/
https://www.ncbi.nlm.nih.gov/pubmed/23991218
http://dx.doi.org/10.1371/journal.pone.0074376