Novel Single Nucleotide Polymorphisms in Interleukin 6 Affect Tacrolimus Metabolism in Liver Transplant Patients

BACKGROUND: Tacrolimus is the first-line immunosuppressant after organ transplantation. It is mainly metabolized by cytochrome P450, family 3, subfamily A (CYP3A) enzymes, but there are large individual differences in metabolism. Interleukin 6 (IL6) has been shown to cause a pan-suppression of mRNA...

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Detalles Bibliográficos
Autores principales: Chen, Dawei, Fan, Junwei, Guo, Feng, Qin, Shengying, Wang, Zhaowen, Peng, Zhihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753270/
https://www.ncbi.nlm.nih.gov/pubmed/23991193
http://dx.doi.org/10.1371/journal.pone.0073405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753270/
https://www.ncbi.nlm.nih.gov/pubmed/23991193
http://dx.doi.org/10.1371/journal.pone.0073405

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