The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-secretase that initiates Aβ production in Alzheimer’s disease (AD). BACE1 levels are increased in AD, which could contribute to pathogenesis, yet the mechanism of BACE1 elevation is unclear. Furthermore, the normal function of...

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Detalles Bibliográficos
Autores principales: Kandalepas, Patty C., Sadleir, Katherine R., Eimer, William A., Zhao, Jie, Nicholson, Daniel A., Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753469/
https://www.ncbi.nlm.nih.gov/pubmed/23820808
http://dx.doi.org/10.1007/s00401-013-1152-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753469/
https://www.ncbi.nlm.nih.gov/pubmed/23820808
http://dx.doi.org/10.1007/s00401-013-1152-3

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