Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

The recently identified GGGGCC repeat expansion in the noncoding region of C9ORF72 is the most common pathogenic mutation in patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). We generated a human neuronal model and investigated the pathological phenotypes of human n...

Descripción completa

Detalles Bibliográficos
Autores principales: Almeida, Sandra, Gascon, Eduardo, Tran, Hélène, Chou, Hsin Jung, Gendron, Tania F., DeGroot, Steven, Tapper, Andrew R., Sellier, Chantal, Charlet-Berguerand, Nicolas, Karydas, Anna, Seeley, William W., Boxer, Adam L., Petrucelli, Leonard, Miller, Bruce L., Gao, Fen-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753484/
https://www.ncbi.nlm.nih.gov/pubmed/23836290
http://dx.doi.org/10.1007/s00401-013-1149-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753484/
https://www.ncbi.nlm.nih.gov/pubmed/23836290
http://dx.doi.org/10.1007/s00401-013-1149-y

Ejemplares similares