Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels

Human ether-à-go-go–related gene (hERG, Kv11.1) potassium channels have unusually slow activation and deactivation kinetics. It has been suggested that, in fast-activating Shaker channels, a highly conserved Phe residue (F290) in the S2 segment forms a putative gating charge transfer center that int...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Yen May, Hull, Christina M., Niven, Christine M., Qi, Ji, Allard, Charlene R., Claydon, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753600/
https://www.ncbi.nlm.nih.gov/pubmed/23980197
http://dx.doi.org/10.1085/jgp.201310992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753600/
https://www.ncbi.nlm.nih.gov/pubmed/23980197
http://dx.doi.org/10.1085/jgp.201310992

Ejemplares similares