DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

RNA synthesis and DNA replication cease after DNA damage. We studied RNA synthesis using an in situ run-on assay and found ribosomal RNA (rRNA) synthesis was inhibited 24 h after UV light, gamma radiation or DNA cross-linking by cisplatin in human cells. Cisplatin led to accumulation of cells in S p...

Descripción completa

Detalles Bibliográficos
Autores principales: Calkins, Anne S., Iglehart, J. Dirk, Lazaro, Jean-Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753630/
https://www.ncbi.nlm.nih.gov/pubmed/23775790
http://dx.doi.org/10.1093/nar/gkt502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753630/
https://www.ncbi.nlm.nih.gov/pubmed/23775790
http://dx.doi.org/10.1093/nar/gkt502

Ejemplares similares