DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data sup...

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Detalles Bibliográficos
Autores principales: Qin, Zhoushuai, Lu, Mengxue, Xu, Xin, Hanna, Michelle, Shiomi, Naoko, Xiao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753651/
https://www.ncbi.nlm.nih.gov/pubmed/23761444
http://dx.doi.org/10.1093/nar/gkt542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753651/
https://www.ncbi.nlm.nih.gov/pubmed/23761444
http://dx.doi.org/10.1093/nar/gkt542

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