Cargando…

DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

In response to replication-blocking lesions, proliferating cell nuclear antigen (PCNA) can be sequentially ubiquitinated at the K164 residue, leading to two modes of DNA-damage tolerance, namely, translesion DNA synthesis (TLS) and error-free lesion bypass. Although the majority of reported data sup...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Zhoushuai, Lu, Mengxue, Xu, Xin, Hanna, Michelle, Shiomi, Naoko, Xiao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753651/ https://www.ncbi.nlm.nih.gov/pubmed/23761444 http://dx.doi.org/10.1093/nar/gkt542

Ejemplares similares

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells
por: Bhat, Audesh, et al.
Publicado: (2013)

Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities
por: Pastushok, Landon, et al.
Publicado: (2010)

FF(483–484) motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance
por: Baldeck, Nadège, et al.
Publicado: (2015)

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts
por: Schmutz, Valérie, et al.
Publicado: (2010)

Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle
por: Bertoletti, Federica, et al.
Publicado: (2017)

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage
por: Wit, Niek, et al.
Publicado: (2015)

Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
por: Masuda, Yuji, et al.
Publicado: (2018)

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ
por: Tomida, Junya, et al.
Publicado: (2015)

PCNA monoubiquitylation and DNA polymerase η ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae
por: van der Kemp, Patricia Auffret, et al.
Publicado: (2009)

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks
por: Durando, Michael, et al.
Publicado: (2013)

Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance
por: Juhasz, Szilvia, et al.
Publicado: (2012)

Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA
por: Takahashi, Diane T, et al.
Publicado: (2020)

Polymerase η suppresses telomere defects induced by DNA damaging agents
por: Pope-Varsalona, Hannah, et al.
Publicado: (2014)

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA
por: Lau, Wilson C. Y., et al.
Publicado: (2015)

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
por: Mortusewicz, Oliver, et al.
Publicado: (2011)

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
por: Becker, Jordan R, et al.
Publicado: (2018)

Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes
por: Ghazi, Madeeha, et al.
Publicado: (2023)

ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe
por: Sastre-Moreno, Guillermo, et al.
Publicado: (2014)

Role of SUMO modification of human PCNA at stalled replication fork
por: Gali, Himabindu, et al.
Publicado: (2012)

PCNA promotes processive DNA end resection by Exo1
por: Chen, Xiaoqing, et al.
Publicado: (2013)

Role of PCNA-dependent stimulation of 3′-phosphodiesterase and 3′–5′ exonuclease activities of human Ape2 in repair of oxidative DNA damage
por: Burkovics, Peter, et al.
Publicado: (2009)

Critical amino acids in human DNA polymerases η and κ involved in erroneous incorporation of oxidized nucleotides
por: Katafuchi, Atsushi, et al.
Publicado: (2010)

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks
por: Rohleder, Florian, et al.
Publicado: (2016)

PCNA tool belts and polymerase bridges form during translesion synthesis
por: Boehm, Elizabeth M., et al.
Publicado: (2016)

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation
por: Guarino, Estrella, et al.
Publicado: (2011)

REV1 and polymerase ζ facilitate homologous recombination repair
por: Sharma, Shilpy, et al.
Publicado: (2012)

The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesis
por: Zhou, Ying, et al.
Publicado: (2010)

DNA polymerase η contributes to genome-wide lagging strand synthesis
por: Kreisel, Katrin, et al.
Publicado: (2019)

The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA
por: Saugar, Irene, et al.
Publicado: (2012)

PCNA directs type 2 RNase H activity on DNA replication and repair substrates
por: Bubeck, Doryen, et al.
Publicado: (2011)

Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1
por: Xu, Xin, et al.
Publicado: (2016)

PIP degron proteins, substrates of CRL4(Cdt2), and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage
por: Tsanov, Nikolay, et al.
Publicado: (2014)

Polμ tumor variants decrease the efficiency and accuracy of NHEJ
por: Sastre-Moreno, Guillermo, et al.
Publicado: (2017)

Unencumbered Pol β lyase activity in nucleosome core particles
por: Rodriguez, Yesenia, et al.
Publicado: (2017)

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
por: Cazzalini, Ornella, et al.
Publicado: (2014)

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex
por: Paul Solomon Devakumar, Lovely Jael, et al.
Publicado: (2019)

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases δ and η
por: McCulloch, Scott D., et al.
Publicado: (2009)

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis
por: Pilzecker, Bas, et al.
Publicado: (2016)

The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis
por: Burkovics, Peter, et al.
Publicado: (2016)

Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination
por: Park, Su Hyung, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rtlnifql7kv4lv38hnqjtfogrc