Cargando…

Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA: Possible Role in Proliferative Diabetic Retinopathy

Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elshaer, Sally L., Abdelsaid, Mohammed A., Al-Azayzih, Ahmad, Kumar, Parag, Matragoon, Suraporn, Nussbaum, Julian J., El-Remessy, Azza B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753742/ https://www.ncbi.nlm.nih.gov/pubmed/23998130 http://dx.doi.org/10.1155/2013/432659

Ejemplares similares

Deletion of Thioredoxin Interacting Protein (TXNIP) Augments Hyperoxia-Induced Vaso-Obliteration in a Mouse Model of Oxygen Induced-Retinopathy
por: Abdelsaid, Mohammed A., et al.
Publicado: (2014)

Deletion of p75(NTR) prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model
por: Elshaer, Sally L., et al.
Publicado: (2018)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation
por: El-Remessy, Azza B., et al.
Publicado: (2010)

Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina
por: Shanab, Ahmed Y, et al.
Publicado: (2015)

Electroporation-mediated gene delivery of cleavage-resistant pro–nerve growth factor causes retinal neuro- and vascular degeneration
por: Matragoon, Suraporn, et al.
Publicado: (2012)

TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines
por: Pasini, Luigi, et al.
Publicado: (2015)

Molecular Mechanisms of Diabetic Retinopathy: Potential Therapeutic Targets
por: Coucha, Maha, et al.
Publicado: (2015)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway
por: Al-Gayyar, Mohammed M. H., et al.
Publicado: (2013)

MicroRNA-146b-3p Regulates Retinal Inflammation by Suppressing Adenosine Deaminase-2 in Diabetes
por: Fulzele, Sadanand, et al.
Publicado: (2015)

Alteration of growth factors and neuronal death in diabetic retinopathy: what we have learned so far
por: Whitmire, Will, et al.
Publicado: (2011)

Diabetes exacerbates retinal oxidative stress, inflammation, and microvascular degeneration in spontaneously hypertensive rats
por: Mohamed, Islam N., et al.
Publicado: (2012)

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors
por: Brahimi, Fouad, et al.
Publicado: (2014)

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
por: Barford, Kelly, et al.
Publicado: (2018)

Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
por: Sui, Tongtong, et al.
Publicado: (2021)

NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Publicado: (1995)

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
por: Pryor, Shona, et al.
Publicado: (2012)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
por: Feinberg, Konstantin, et al.
Publicado: (2017)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
por: Calvo-Enrique, Laura, et al.
Publicado: (2023)

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization
por: O-Sullivan, InSug, et al.
Publicado: (2022)

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes
por: Ibrahim, Ahmed S., et al.
Publicado: (2011)

High Glucose-Mediated Tyrosine Nitration of PI3-Kinase: A Molecular Switch of Survival and Apoptosis in Endothelial Cells
por: Elshaer, Sally L., et al.
Publicado: (2018)

Gating of the TrkH Ion Channel by its Associated RCK Protein, Trka
por: Cao, Yu, et al.
Publicado: (2013)

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors
por: Toni, T, et al.
Publicado: (2014)

Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction
por: Hou, Yi, et al.
Publicado: (2017)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
por: Ye, Mengchen, et al.
Publicado: (2018)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation
por: Josephy-Hernandez, Sylvia, et al.
Publicado: (2019)

TrkA(+) Neurons Induce Pathologic Regeneration After Soft Tissue Trauma
por: Cherief, Masnsen, et al.
Publicado: (2022)

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
por: Zhang, Hanzhi, et al.
Publicado: (2020)

Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor
por: Gorokhova, Svetlana, et al.
Publicado: (2014)

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes
por: Shao, Yufang, et al.
Publicado: (2002)

SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
por: Marsh, H. Nicholas, et al.
Publicado: (2003)

Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis
por: Raychaudhuri, Smriti K, et al.
Publicado: (2010)

Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors
por: Raeppel, Stéphane L., et al.
Publicado: (2012)

Crystal Structure of a Two-Subunit TrkA Octameric Gating Ring Assembly
por: Deller, Marc C., et al.
Publicado: (2015)

Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
por: Canu, Nadia, et al.
Publicado: (2017)

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
por: Omerbašić, Damir, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_20drou8jea0lfn1trqtnvv0opg