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Mechanism of activation of elongation factor Tu by ribosome: Catalytic histidine activates GTP by protonation

Elongation factor Tu (EF-Tu) is central to prokaryotic protein synthesis as it has the role of delivering amino-acylated tRNAs to the ribosome. Release of EF-Tu, after correct binding of the EF-Tu:aa-tRNA complex to the ribosome, is initiated by GTP hydrolysis. This reaction, whose mechanism is unce...

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Detalles Bibliográficos
Autores principales: Aleksandrov, Alexey, Field, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753929/
https://www.ncbi.nlm.nih.gov/pubmed/23864225
http://dx.doi.org/10.1261/rna.040097.113