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Mechanism of activation of elongation factor Tu by ribosome: Catalytic histidine activates GTP by protonation
Elongation factor Tu (EF-Tu) is central to prokaryotic protein synthesis as it has the role of delivering amino-acylated tRNAs to the ribosome. Release of EF-Tu, after correct binding of the EF-Tu:aa-tRNA complex to the ribosome, is initiated by GTP hydrolysis. This reaction, whose mechanism is unce...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753929/ https://www.ncbi.nlm.nih.gov/pubmed/23864225 http://dx.doi.org/10.1261/rna.040097.113 |