DNA-PKcs Inhibition Sensitizes Cancer Cells to Carbon-Ion Irradiation via Telomere Capping Disruption

Heavy-ion irradiation induces a higher frequency of DNA double strand breaks (DSBs) which must be properly repaired. Critical shortening of telomeres can trigger DNA damage responses such as DSBs. Telomeres are very sensitive to oxidative stress such as ionizing radiation. The DNA-dependent protein...

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Detalles Bibliográficos
Autores principales: Zhou, Xin, Zhang, Xin, Xie, Yi, Tanaka, Kaoru, Wang, Bing, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754927/
https://www.ncbi.nlm.nih.gov/pubmed/24013362
http://dx.doi.org/10.1371/journal.pone.0072641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754927/
https://www.ncbi.nlm.nih.gov/pubmed/24013362
http://dx.doi.org/10.1371/journal.pone.0072641

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