Phosphorylation Status of 72 kDa MMP-2 Determines Its Structure and Activity in Response to Peroxynitrite

Matrix metalloproteinase-2 (MMP-2) is a key intra- and extra-cellular protease which contributes to several oxidative stress related pathologies. A molecular understanding of 72 kDa MMP-2 activity, directly mediated by S-glutathiolation of its cysteine residues in the presence of peroxynitrite (ONOO...

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Detalles Bibliográficos
Autores principales: Jacob-Ferreira, Anna Laura, Kondo, Marcia Yuri, Baral, Pravas Kumar, James, Michael N. G., Holt, Andrew, Fan, Xiaohu, Schulz, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754950/
https://www.ncbi.nlm.nih.gov/pubmed/24013357
http://dx.doi.org/10.1371/journal.pone.0071794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754950/
https://www.ncbi.nlm.nih.gov/pubmed/24013357
http://dx.doi.org/10.1371/journal.pone.0071794

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