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Examination of Artificial MiRNA Mimics with Centered–Site Complementarity for Gene Targeting
BACKGROUND: MiRNA primarily acts to repress gene expression at the post-transcriptional level through imperfect complementarity of its 5′ region to the “seed site” in the 3′ untranslated region of target mRNAs, with its “3′–supplementary site” and “center site” also playing important roles under cer...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754971/ https://www.ncbi.nlm.nih.gov/pubmed/24013456 http://dx.doi.org/10.1371/journal.pone.0072062 |