The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive bre...

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Detalles Bibliográficos
Autores principales: Xu, Wei, Lacerda, Lara, Debeb, Bisrat G., Atkinson, Rachel L., Solley, Travis N., Li, Li, Orton, Darren, McMurray, John S., Hang, Brian I., Lee, Ethan, Klopp, Ann H., Ueno, Naoto T., Reuben, James M., Krishnamurthy, Savitri, Woodward, Wendy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754994/
https://www.ncbi.nlm.nih.gov/pubmed/24013655
http://dx.doi.org/10.1371/journal.pone.0071508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754994/
https://www.ncbi.nlm.nih.gov/pubmed/24013655
http://dx.doi.org/10.1371/journal.pone.0071508

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