Combined Treatment with Low Concentrations of Decitabine and SAHA Causes Cell Death in Leukemic Cell Lines but Not in Normal Peripheral Blood Lymphocytes

Epigenetic therapy reverting aberrant acetylation or methylation offers the possibility to target preferentially tumor cells and to preserve normal cells. Combination epigenetic therapy may further improve the effect of individual drugs. We investigated combined action of demethylating agent decitab...

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Detalles Bibliográficos
Autores principales: Brodská, Barbora, Holoubek, Aleš, Otevřelová, Petra, Kuželová, Kateřina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755446/
https://www.ncbi.nlm.nih.gov/pubmed/24000324
http://dx.doi.org/10.1155/2013/659254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755446/
https://www.ncbi.nlm.nih.gov/pubmed/24000324
http://dx.doi.org/10.1155/2013/659254

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