Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

Forkhead transcription factors FoxO1/3/4 have pleiotrophic functions including anti-oxidative stress and metabolism. With regard to glucose metabolism, most studies have been focused on FoxO1. To further investigate their hepatic functions, we generated liver-specific FoxO1/3/4 knockout mice (LTKO)...

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Detalles Bibliográficos
Autores principales: Xiong, Xiwen, Tao, Rongya, DePinho, Ronald A., Dong, X. Charlie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755981/
https://www.ncbi.nlm.nih.gov/pubmed/24015318
http://dx.doi.org/10.1371/journal.pone.0074340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755981/
https://www.ncbi.nlm.nih.gov/pubmed/24015318
http://dx.doi.org/10.1371/journal.pone.0074340

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