Development and Validation of Non-Integrative, Self-Limited, and Replicating Minicircles for Safe Reporter Gene Imaging of Cell-Based Therapies

Reporter gene (RG) imaging of cell-based therapies provides a direct readout of therapeutic efficacy by assessing the fate of implanted cells. To permit long-term cellular imaging, RGs are traditionally required to be integrated into the cellular genome. This poses a potential safety risk and regula...

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Detalles Bibliográficos
Autores principales: Ronald, John A., Cusso, Lorena, Chuang, Hui-Yen, Yan, Xinrui, Dragulescu-Andrasi, Anca, Gambhir, Sanjiv Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756008/
https://www.ncbi.nlm.nih.gov/pubmed/24015294
http://dx.doi.org/10.1371/journal.pone.0073138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756008/
https://www.ncbi.nlm.nih.gov/pubmed/24015294
http://dx.doi.org/10.1371/journal.pone.0073138

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