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Increased Risk of Q151M and K65R Mutations in Patients Failing Stavudine-Containing First-Line Antiretroviral Therapy in Cambodia

BACKGROUND: Multi-nucleos(t)ide resistance (MNR) mutations including Q151M, K65R mutations, and insertion at codon 69 of HIV-1 reverse transcriptase coding region may confer resistance to all molecules of nucleos(t)ide reverse transcriptase inhibitors (NRTI). The presence of these mutations is an em...

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Detalles Bibliográficos
Autores principales: Nouhin, Janin, Madec, Yoann, Ngo-Giang-Huong, Nicole, Ferradini, Laurent, Nerrienet, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756052/
https://www.ncbi.nlm.nih.gov/pubmed/24015311
http://dx.doi.org/10.1371/journal.pone.0073744