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Altered DNA Methylation Patterns of the H19 Differentially Methylated Region and the DAZL Gene Promoter Are Associated with Defective Human Sperm

DNA methylation disturbance is associated with defective human sperm. However, oligozoospermia (OZ) and asthenozoospermia (AZ) usually present together, and the relationship between the single-phenotype defects in human sperm and DNA methylation is poorly understood. In this study, 20 infertile OZ p...

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Detalles Bibliográficos
Autores principales: Li, Bo, Li, Jian-bo, Xiao, Xi-feng, Ma, Ye-fei, Wang, Jun, Liang, Xin-xin, Zhao, Hong-xi, Jiang, Feng, Yao, Yuan-qing, Wang, Xiao-hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756053/
https://www.ncbi.nlm.nih.gov/pubmed/24015185
http://dx.doi.org/10.1371/journal.pone.0071215