Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity, e.g., by interference with transcription and/or DNA replication mechanisms. Additionally, cisplatin damages tumors via in...

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Detalles Bibliográficos
Autores principales: Florea, Ana-Maria, Büsselberg, Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756417/
https://www.ncbi.nlm.nih.gov/pubmed/24212665
http://dx.doi.org/10.3390/cancers3011351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756417/
https://www.ncbi.nlm.nih.gov/pubmed/24212665
http://dx.doi.org/10.3390/cancers3011351

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