Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

Expression of long-lasting synaptic plasticity and long-term memory requires new protein synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2α subunit (eIF2α). It was reported previously that eIF2α phosphorylation is elevated in the brains of Alzheimer’s disease (AD...

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Detalles Bibliográficos
Autores principales: Ma, Tao, Trinh, Mimi A., Wexler, Alyse J., Bourbon, Clarisse, Gatti, Evelina, Pierre, Philippe, Cavener, Douglas R., Klann, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756900/
https://www.ncbi.nlm.nih.gov/pubmed/23933749
http://dx.doi.org/10.1038/nn.3486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756900/
https://www.ncbi.nlm.nih.gov/pubmed/23933749
http://dx.doi.org/10.1038/nn.3486

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