p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

Chromosomal region maintenance 1 (CRM1) mediates p53 nuclear export. Although p53 SUMOylation promotes its nuclear export, the underlying mechanism is unclear. Here we show that tethering of a small, ubiquitin-like modifier (SUMO) moiety to p53 markedly increases its cytoplasmic localization. SUMO a...

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Detalles Bibliográficos
Autores principales: Santiago, Aleixo, Li, Dawei, Zhao, Lisa Y., Godsey, Adam, Liao, Daiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756925/
https://www.ncbi.nlm.nih.gov/pubmed/23825024
http://dx.doi.org/10.1091/mbc.E12-10-0771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756925/
https://www.ncbi.nlm.nih.gov/pubmed/23825024
http://dx.doi.org/10.1091/mbc.E12-10-0771

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