Phospholipase D Toxins of Brown Spider Venom Convert Lysophosphatidylcholine and Sphingomyelin to Cyclic Phosphates

Venoms of brown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans. These toxins cleave the substrates sphingomyelin and lysophosphatidylcholine in mammalian tissues, releasing the choline head group. The other products...

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Detalles Bibliográficos
Autores principales: Lajoie, Daniel M., Zobel-Thropp, Pamela A., Kumirov, Vlad K., Bandarian, Vahe, Binford, Greta J., Cordes, Matthew H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756997/
https://www.ncbi.nlm.nih.gov/pubmed/24009677
http://dx.doi.org/10.1371/journal.pone.0072372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756997/
https://www.ncbi.nlm.nih.gov/pubmed/24009677
http://dx.doi.org/10.1371/journal.pone.0072372

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