Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

A non-toxic, nine residue peptide, NIVNVSLVK is shown to interfere with insulin fibrillation by various biophysical methods. Insulin undergoes conformational changes under certain stress conditions leading to amyloid fibrils. Fibrillation of insulin poses a problem in its long-term storage, reducing...

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Detalles Bibliográficos
Autores principales: Banerjee, Victor, Kar, Rajiv K., Datta, Aritreyee, Parthasarathi, Krupakar, Chatterjee, Subhrangsu, Das, Kali P., Bhunia, Anirban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756998/
https://www.ncbi.nlm.nih.gov/pubmed/24009675
http://dx.doi.org/10.1371/journal.pone.0072318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756998/
https://www.ncbi.nlm.nih.gov/pubmed/24009675
http://dx.doi.org/10.1371/journal.pone.0072318

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