Acetylation of Drosha on the N-Terminus Inhibits Its Degradation by Ubiquitination

The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expres...

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Detalles Bibliográficos
Autores principales: Tang, Xiaoli, Wen, Sicheng, Zheng, Dong, Tucker, Lynne, Cao, Lulu, Pantazatos, Dennis, Moss, Steven F., Ramratnam, Bharat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://www.ncbi.nlm.nih.gov/pubmed/24009686
http://dx.doi.org/10.1371/journal.pone.0072503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757024/
https://www.ncbi.nlm.nih.gov/pubmed/24009686
http://dx.doi.org/10.1371/journal.pone.0072503

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