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Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools
Stoichiometric models of metabolism, such as flux balance analysis (FBA), are classically applied to predicting steady state rates - or fluxes - of metabolic reactions in genome-scale metabolic networks. Here we revisit the central assumption of FBA, i.e. that intracellular metabolites are at steady...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757068/ https://www.ncbi.nlm.nih.gov/pubmed/24009492 http://dx.doi.org/10.1371/journal.pcbi.1003195 |