High-Throughput Genetic and Gene Expression Analysis of the RNAPII-CTD Reveals Unexpected Connections to SRB10/CDK8

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction, chromatin immunoprecipitation followed by microarrays (ChIP-on-chip) and mRNA expression analysis, we found that truncating t...

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Detalles Bibliográficos
Autores principales: Aristizabal, Maria J., Negri, Gian Luca, Benschop, Joris J., Holstege, Frank C. P., Krogan, Nevan J., Kobor, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757075/
https://www.ncbi.nlm.nih.gov/pubmed/24009531
http://dx.doi.org/10.1371/journal.pgen.1003758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757075/
https://www.ncbi.nlm.nih.gov/pubmed/24009531
http://dx.doi.org/10.1371/journal.pgen.1003758

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