Cargando…
High-Throughput Genetic and Gene Expression Analysis of the RNAPII-CTD Reveals Unexpected Connections to SRB10/CDK8
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction, chromatin immunoprecipitation followed by microarrays (ChIP-on-chip) and mRNA expression analysis, we found that truncating t...
Autores principales: | Aristizabal, Maria J., Negri, Gian Luca, Benschop, Joris J., Holstege, Frank C. P., Krogan, Nevan J., Kobor, Michael S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757075/ https://www.ncbi.nlm.nih.gov/pubmed/24009531 http://dx.doi.org/10.1371/journal.pgen.1003758 |
Ejemplares similares
-
The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition
por: Aristizabal, Maria J., et al.
Publicado: (2015) -
A single flexible RNAPII-CTD integrates many different transcriptional programs
por: Aristizabal, Maria J., et al.
Publicado: (2016) -
A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation
por: Chen, Yupeng, et al.
Publicado: (2014) -
Conditional Genetic Interactions of RTT107, SLX4, and HRQ1 Reveal Dynamic Networks upon DNA Damage in S. cerevisiae
por: Leung, Grace P., et al.
Publicado: (2014) -
The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach
por: Odawara, Jun, et al.
Publicado: (2011)