Pharmacological targeting of the PI3K/mTOR pathway alters the release of angioregulatory mediators both from primary human acute myeloid leukemia cells and their neighboring stromal cells

Acute myeloid leukemia (AML) is a heterogeneous and aggressive malignancy with poor overall survival. Constitutive as well as cytokine-initiated activation of PI3K/Akt/mTOR signaling is a common feature of AML patients, and inhibition of this pathway is considered as a possible therapeutic strategy...

Descripción completa

Detalles Bibliográficos
Autores principales: Reikvam, Håkon, Nepstad, Ina, Bruserud, Øystein, Hatfield, Kimberley Joanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757241/
https://www.ncbi.nlm.nih.gov/pubmed/23919981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757241/
https://www.ncbi.nlm.nih.gov/pubmed/23919981

Ejemplares similares