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Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

Multiple myeloma (MM) is a malignancy characterized by the accumulation of clonal plasma cells in the bone marrow. Despite extensive efforts to design drugs targeting tumoral cells and their microenvironment, MM remains an incurable disease for which new therapeutic strategies are needed. We demonst...

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Detalles Bibliográficos
Autores principales: Sola, Brigitte, Poirot, Marc, de Medina, Philippe, Bustany, Sophie, Marsaud, Véronique, Silvente-Poirot, Sandrine, Renoir, Jack-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757248/
https://www.ncbi.nlm.nih.gov/pubmed/23978789