Loss of NPC1 function in a patient with a co-inherited novel insulin receptor mutation does not grossly modify the severity of the associated insulin resistance

In Npc1 null mice, a model for Niemann Pick Disease Type C1, it has been reported that hepatocyte insulin receptor function is significantly impaired, consistent with growing evidence that membrane fluidity and microdomain structure have an important role in insulin signal transduction. However, whe...

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Detalles Bibliográficos
Autores principales: Kirk, J., Porter, K. M., Parker, V., Barroso, I., O’Rahilly, S., Hendriksz, C., Semple, R. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757264/
https://www.ncbi.nlm.nih.gov/pubmed/20521171
http://dx.doi.org/10.1007/s10545-010-9107-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757264/
https://www.ncbi.nlm.nih.gov/pubmed/20521171
http://dx.doi.org/10.1007/s10545-010-9107-5

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