FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targets such as Notch1, c-Jun, and cyclin E that function in critical developmental and signalling pathways. Mutations in FBXW7 are often found in many types of cancer. In most cases, these mutations do n...

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Detalles Bibliográficos
Autores principales: Davis, Hayley, Lewis, Annabelle, Spencer-Dene, Bradley, Tateossian, Hilda, Stamp, Gordon, Behrens, Axel, Tomlinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2011
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757315/
https://www.ncbi.nlm.nih.gov/pubmed/21503901
http://dx.doi.org/10.1002/path.2874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757315/
https://www.ncbi.nlm.nih.gov/pubmed/21503901
http://dx.doi.org/10.1002/path.2874

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