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Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wn...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757404/ https://www.ncbi.nlm.nih.gov/pubmed/24212796 http://dx.doi.org/10.3390/cancers3022050 |
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author | Valkenburg, Kenneth C. Graveel, Carrie R. Zylstra-Diegel, Cassandra R. Zhong, Zhendong Williams, Bart O. |
author_facet | Valkenburg, Kenneth C. Graveel, Carrie R. Zylstra-Diegel, Cassandra R. Zhong, Zhendong Williams, Bart O. |
author_sort | Valkenburg, Kenneth C. |
collection | PubMed |
description | The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling. |
format | Online Article Text |
id | pubmed-3757404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37574042013-09-04 Wnt/β-catenin Signaling in Normal and Cancer Stem Cells Valkenburg, Kenneth C. Graveel, Carrie R. Zylstra-Diegel, Cassandra R. Zhong, Zhendong Williams, Bart O. Cancers (Basel) Review The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. We will also discuss how dysregulation of the pathway is associated with putative cancer stem cells and the potential therapeutic implications of regulating Wnt signaling. Molecular Diversity Preservation International (MDPI) 2011-04-19 /pmc/articles/PMC3757404/ /pubmed/24212796 http://dx.doi.org/10.3390/cancers3022050 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Valkenburg, Kenneth C. Graveel, Carrie R. Zylstra-Diegel, Cassandra R. Zhong, Zhendong Williams, Bart O. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title_full | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title_fullStr | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title_full_unstemmed | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title_short | Wnt/β-catenin Signaling in Normal and Cancer Stem Cells |
title_sort | wnt/β-catenin signaling in normal and cancer stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757404/ https://www.ncbi.nlm.nih.gov/pubmed/24212796 http://dx.doi.org/10.3390/cancers3022050 |
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